Back Module: CBI-1

Competency: 2

This is a compentency for the module "Introduction to Clinical Bioinformatics and Genetics CBI-1".

Competency information

Details

Take a DNA sequence and use standard bioinformatic tools to locate within a genome, annotate and infer function, including gene prediction, transcription factor (TF) analysis, splice-site boundaries, potential for copy number variants (CNVs).

Considerations

  • The genome sequence resources
  • The annotations provided by genome
  • The different types of DNA sequence in databases – complete genome, cDNA, expressed sequenced tags (ESTs), function non- coding
  • Tools for DNA sequence alignment, including those for matching large genomic
  • Resources for non-coding functional genomic regions (databases of transcription factor binding sites, CNVs, ).
  • Resources for alternatively spliced
  • Tools for exon prediction – sequence
  • Tools for exon prediction – signal
  • Tools for transcription factor (TF)
  • The use of literature resources to support function
  • The processes of combining predictive tools to provide evidenced protein
  • Best practice guidelines and QA (both internal and external).

Relevant learning outcomes

# Outcome
# 1 Outcome Perform analysis on DNA data and protein sequence data to infer function.
# 2 Outcome Perform sequence alignment tasks. 
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