Training activity information
Details
Analyse the appropriate genetic tests for gene fusion analysis, to include:
- FISH, e.g. lung cancer
- RT-PCR, e.g. AML, ALL
- RNA Fusion panel, e.g. NTRK
Type
Developmental training activity (DTA)
Evidence requirements
Evidence the activity has been undertaken by the trainee.
Reflection on the activity at one or more time points after the event including learning from the activity and/or areas of the trainees practice for development.
An action plan to implement learning and/or to address skills or knowledge gaps identified.
Considerations
- Prognostic and diagnostic genetic markers
- Selection and analysis in mixed cell populations
- Principles of the assays
- Disease mechanism
- Best practice guidance
- Local and national guidance
- Incidental findings
- Quality control, including IQC, and EQA
- Variant nomenclature (ISCN and HGVS)
- Sensitivity and limitations
- Variant classification (analysis of ‘productive’ versus ‘non-productive’ fusions)
- Local SOPs
- Health and safety
- Follow up/reflex testing options
Relevant learning outcomes
| # | Outcome |
|---|---|
| # 3 |
Outcome
Analyse, interpret and report tests for patients referred with sporadic cancer. |
| # 7 |
Outcome
Analyse, interpret and report gene fusion testing in cancer referrals. |