Back Module: SLS101

Competency: 5

This is a compentency for the module "Immunity and the Principles and Practice of Histocompatibility and Immunogenetics".

Competency information

Details

Interpret laboratory data in the light of clinical details on patients with common disorders where transplantation is the therapy of choice, including at least 2 of the following;

  • Autoimmune disorders
  • Immunodeficiency disorders
  • Renal disorders
  • Other solid organ disorders
  • Haematological malignancies
  • Disease associations
  • Drug hypersensitivity

Considerations

  • Organisation and components of the immune system.
  • Ranges and values needed for interpretation of results.
  • Cellular components (lymphocytes; granulocytes; monocytes/macrophages).
  • Humoral components (autoantibodies, the range of autoantibodies and the role they play in autoimmune disease; immunoglobulins and the importance of their levels and their absence; complement and the importance of their levels and their absence).
  • Central molecules of the immune system (major histocompatibility molecules, classes I ⅈ Cluster of Differentiation (CD) molecules/cell surface markers; receptor molecules; recognition molecules; adhesion molecules; effector molecules).
  • Antigen presentation.
  • Innate immune response (endothelial cells; neutrophils; macrophages; natural killer cells; complement).
  • Adaptive immune response (antigen processing; dendritic cells; T cell responses; B cell responses; primary and secondary responses; vaccination/immunisation).
  • The adaptive immune system routine assays which can be usefully examined in an H&I laboratory.
  • Outcome of immune responses (immunity/immunological memory; direct and indirect functions of antibodies).
  • Major assays performed in an H&I laboratory.

Relevant learning outcomes

# Outcome
# 1 Outcome Interpret routine requests for common H&I investigations in the correct clinical context and process the specimens that accompany those requests.
# 4 Outcome Report the results of commonly performed H&I investigations.
# 5 Outcome Apply the principles of internal quality control and external quality assessment and draw appropriate conclusions about assay performance.
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