Competency information
Details
Perform chimerism analysis to assess and monitor patients post HSCT.
Considerations
- How to assure the quality of personal practice.
- HSC transplant complications including:
- Acute graft versus host disease (GVHD)
- Chronic GVHD
- Graft failure, non-engraftment and delayed engraftment
- Infection
- Relapse in leukaemia, infertility, secondary malignancies
- Local immunosuppression regimes and assessment as to whether immunosuppression is adequate.
- Local protocols for the clinical and laboratory monitoring of patients who have received haematopoietic stem cell transplantation.
- Conditioning regimens and applicability of chimaerism analysis.
- Principles of methods employed for post transplant monitoring including:
- Fluorescence in-situ hybridisation (FISH)
- Minimal Residual Disease Monitoring
- STR/microsatellite analysis
- Real-time PCR
- Relevance of Cell Lineage Analysis.
- National guidelines for chimerism analysis.
- The need to manage records and all other information in accordance with applicable legislation, protocols and guidelines.
Relevant learning outcomes
| # | Outcome |
|---|---|
| # 1 | Outcome Perform the clinical and laboratory investigation of patients being considered for HSCT including the interpretation and reporting of results in the correct clinical context. |
| # 4 | Outcome Perform clinical and laboratory monitoring of patients who have received haematopoietic stem cell transplantation. |