Back Module: SLS131

Competency: 1

This is a compentency for the module "Hematological Malignancy".

Competency information

Details

Perform a range of methods for diagnosing and monitoring treatment of haematological malignancy, including:

  • morphology screening
  • immunophenotyping by flow cytometry
  • karyotyping
  • fluorescence in-situ hybridisation panels
  • molecular diagnostics, including:
  • IgH gene rearrangement
  • TCR gene rearrangement
  • BCRABL
  • JAK2
  • FLT3/NPMI
  • minimal residual disease monitoring
  • post-transplant chimera monitoring.

Considerations

  • The principles underlying the methods listed.
  • Understanding of BCSH guidelines for selection of appropriate tests.
  • Relevant white cell morphology (bone marrow and peripheral blood).
  • Cytogenetic abnormalities commonly associated with haematological disease.
  • A minimum of two molecular tests from the following list:
    • IgH gene rearrangement
    • TCR gene rearrangement
    • BCRABL
    • JAK2
    • FLT3/NPMI
    • minimal residual disease monitoring
    • post-transplant chimera monitoring.
  • The need for internal and external quality assessment and how to remedy poor performance.

Relevant learning outcomes

# Outcome
# 1 Outcome Perform a range of laboratory and molecular testing techniques used in the workplace to diagnose and monitor treatment of haematological malignancy.
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