Competency information
Details
Interpret and report results in the correct clinical context.
Considerations
- Types of haemolytic anaemias and their management.
- Non-serological:
- hereditary
- mechanical anaemias
- microangiopathy
- infectious agents.
- Serological:
- WAIHA
- cold – primary CHAD, CHAD secondary to HBV
- PCH
- PNH
- drug-induced
- combined warm-cold.
- Non-serological:
- Monospecific DAT, its uses and the limitations:
- harmless DAT positives in donors and patients
- reasons for a positive DAT other than AIHA
- AIHAs with negative DATs
- problems with phenotyping DAT-positive patients and application of genotyping in this situation.
- Autoantibody ’specificities‘ and their effect on transfusion.
- Practical considerations of selecting and cross-matching blood for patients with autoantibodies.
- The methods used to detect and identify red cell alloantibodies in patients with warm and cold reacting autoantibodies, and the frequency of testing required where these patients are transfusion dependent.
- Principles of adsorption elution techniques including
- situations where autoadsoption is not appropriate
- selection of cells for alloadsoption.
Relevant learning outcomes
# | Outcome |
---|---|
# 3 | Outcome Select and perform serological tests for differential diagnosis of autoimmune haemolytic anaemia (AIHA) and for provision of suitable blood for transfusion. |