Competency information
Details
Perform the analysis and interpretation of Prenatal Chromosomal Microarray.
Considerations
- The technical pathway including its limitations and sensitivities, the essential requirement for good laboratory practice and the risks.
- How to identify and describe potential for error, how this is mitigated, its potential effects and the reporting strategy.
- Best practice guidelines compared with laboratory practice and the differences between the two.
- The concept of incidental findings and guidance for reporting these results.
- Confined placental mosaicism (CPM), its origins and effects for both the fetus and the test and technical testing which may be required.
- Maternal cell contamination (MCC).
- How to identify, quantify and qualify MCC and further technical testing which may be required.
- Fetal mosaicism, its origins and effects for both the fetus and the test and further technical testing which may be required.
- Polysomy, its origins and effects for both the fetus and the test and further technical testing which may be required.
- Validation and verification of findings.
- Describe how findings are classified, from benign to pathogenic.
Relevant learning outcomes
| # | Outcome |
|---|---|
| # 1 | Outcome Apply an appropriate testing strategy (the right sample, the right test, for the right reasons) meeting all relevant KPIs (key performance indicators, however defined). |
| # 2 | Outcome Analyse and interpret results of specific defined tests. |
| # 3 | Outcome Identify and respond appropriately to results. |
| # 5 | Outcome Act in accordance with the high level of laboratory risk associated with prenatal testing and within limits of their responsibilities. |