Competency information
Details
Perform gene fusion analysis using appropriate current technology on oncology samples.
- As examples: sporadic colorectal cancer, lung cancer and leukaemia (CML, ALL and AML).
Considerations
- Rearrangements and translocations commonly associated with solid tissue cancer and named leukaemic types, as well as their clinical significance.
- Principles of main technologies (apart from chromosome analysis) utilised in the identification of rearrangements associated with cancer.
- Use of appropriate nomenclature for reporting gene fusions according to the technology utilised.
- Best practice guidelines for gene fusion analysis technologies in cancer patients (internal and external QA).
Relevant learning outcomes
| # | Outcome |
|---|---|
| # 1 | Outcome Apply appropriate sample selection criteria, taking into account the implications of acquired sporadic cancer with respect to sampling mixed cell populations, limits of detection, sensitivity of assay and patient management. |
| # 2 | Outcome Apply an appropriate testing strategy for the commonly referred acquired sporadic cancers at all stages of the patient pathway. |
| # 3 | Outcome Perform targeted testing for patients referred with sporadic cancer. |