Competency information
Details
Perform appropriate molecular testing on various cancer samples.
Considerations
- Principles underpinning current methods of mutation detection and genetic changes.
- The use and limitations of a range of sample types to analyse tumour DNA.
- Hot-spot mutation and multiple gene panel analysis associated with a number of cancer types.
- Utility and limitations of whole genome sequencing.
- Appropriate use of controls.
- Sensitivity of different testing methodologies and the relevance to mixed cell populations.
- The use of HGVS guidance for reporting of sequence variation in acquired disease.
Relevant learning outcomes
| # | Outcome |
|---|---|
| # 1 | Outcome Apply appropriate sample selection criteria, taking into account the implications of acquired sporadic cancer with respect to sampling mixed cell populations, limits of detection, sensitivity of assay and patient management. |
| # 2 | Outcome Apply an appropriate testing strategy for the commonly referred acquired sporadic cancers at all stages of the patient pathway. |
| # 3 | Outcome Perform targeted testing for patients referred with sporadic cancer. |