Competency information
Details
Select and perform the correct genetic tests(s) for samples from patients referred with colorectal cancer
Considerations
- The technical pathway including its limitations and sensitivities and the essential requirement for good laboratory practice and the risks.
- How to identify and describe the potential for error, how this is mitigated and its potential effects.
- Best practice guidelines compared with laboratory practice and any differences between the two.
- Clinical and scientific aspects of colorectal cancer including microsatellite instability and immunohistochemistry.
- Identify the common gene hotspots for MMR
- The use of HGVS.
- Internal and external quality assurance (QA).
- Local laboratory procedures for recording results of genetic analysis.
- How to critically appraise relevant literature and databases.
- Evaluate how these results impact the diagnostic pathway e.g. reflex testing
Relevant learning outcomes
# | Outcome |
---|---|
# 3 | Outcome Apply the appropriate testing strategy for patients referred for diagnostic testing for colorectal cancer and melanoma |
# 4 | Outcome Perform the appropriate level of molecular diagnostic testing and monitoring for colorectal cancer and melanoma dependent on histopathological findings |
# 5 | Outcome Apply the principles of internal quality control and external quality assessment and draw conclusions about assay performance |