Competency information
Details
Perform and interpret genetic analysis for monitoring of patients with chronic myeloid leukaemia
Considerations
- Health and safety requirements for processing of fresh peripheral blood or bone marrow samples
- Principles of technologies used for monitoring of patients with CML (eg quantitative PCR)
- Internal quality control for assays
- Importance of external quality assurance
- Role of validation and verification of procedures and equipment
- Understanding of assay accreditation and ISO 15189 or equivalent
- National guidelines for pathways and procedures
- Factors affecting quality of samples for molecular monitoring
- Guidelines for reporting BCR-ABL1 quantification (including the International Scale as appropriate)
- Limit of detection of monitoring assays
- Guidelines for the optimal response to TKI based on molecular monitoring
Relevant learning outcomes
| # | Outcome |
|---|---|
| # 3 | Outcome Apply the appropriate testing strategy that would lead to the diagnosis of a range haematological malignancies |
| # 4 | Outcome Implement the use of appropriate assays for the diagnoses and monitoring of a range of haematological malignancies |