Competency information
Details
Perform and interpret genetic analysis for the identification of sequence variants within tyrosine kinase domains for patients with sub-optimal response to treatment
Considerations
- Internal quality control for assays
- Importance of external quality assurance
- Role of validation and verification of procedures and equipment
- Understanding of assay accreditation and ISO 15189 or equivalent
- National guidelines for pathways and procedures
- Health and safety requirements for processing of fresh peripheral blood or bone marrow samples
- Principles of relevant techniques for the identification of BCR-ABL1 tyrosine kinase mutations according to current best practice
- Limitations of relevant techniques
- Guidelines for the choice of second and third line TKI
Relevant learning outcomes
| # | Outcome |
|---|---|
| # 3 | Outcome Apply the appropriate testing strategy that would lead to the diagnosis of a range haematological malignancies |
| # 4 | Outcome Implement the use of appropriate assays for the diagnoses and monitoring of a range of haematological malignancies |