Competency information
Details
Assist with the preparation of samples for analysis, selecting the correct sample processing pathway(s) :
- AML
- MDS
- CLL
- Large B cell lymphoma
Considerations
- Health and safety requirements for processing of fresh peripheral blood or bone marrow samples and cell culture
- Cell culture and preparation of G-banded chromosomes
- Factors affecting quality of samples for G-banding of leukaemia samples
- Preparation of slides for analysis from paraffin embedded blocks
- Selection of the appropriate area for analysis (eg morphological assessment of H&E stained slide)
- Principles of relevant technologies
- Health and safety requirements for use of appropriate equipment (eg fluorescence microscope)
- Chromosomal changes in the relevant disorders
- Role of molecular cytogenetics for diagnosis and prognosis
- Application of molecular cytogenetic analysis to guide treatment choice
Relevant learning outcomes
| # | Outcome |
|---|---|
| # 3 | Outcome Apply the appropriate testing strategy for a range of complex myeloid malignancies including AML, MDS, considering the approach for subclassification and prognosis of disease |
| # 5 | Outcome Implement the appropriate testing strategy for a range of lymphoid malignancies including CLL and large B cell lymphomas, including assessment of lymphoid clonality |