Competency information
Details
Analyse and interpret the result of Lymphoid clonality assessment (IG gene rearrangement) to aid the diagnosis of mature lymphoid malignancies
Considerations
- Requirements of the sample for successful nucleic acid extraction
- Health and safety requirements for processing of fresh peripheral blood, bone marrow or paraffin embedded samples
- Principles of molecular genetic approaches for identification clonal IG gene rearrangement
- Choice of appropriate tests according to suspected diagnosis
- Limitations of the procedure including limit of detection, sensitivity and specificity
- Factors affecting quality of molecular results Interpretation of results
- Common artefacts
- International guidelines for the interpretation of gene rearrangement / clonality assays
Relevant learning outcomes
| # | Outcome |
|---|---|
| # 5 | Outcome Implement the appropriate testing strategy for a range of lymphoid malignancies including CLL and large B cell lymphomas, including assessment of lymphoid clonality |
| # 7 | Outcome Interpret and report on the relevant laboratory procedures for the diagnosis of a range of myeloid and lymphoid malignancies |