Haematopoietic stem cell transplantation 1

Details

Title

Haematopoietic stem cell transplantation 1

Type

Stage One

Module code

HLS040

Requirement

Compulsory

Module objective

By the end of the training period trainees will, with respect to the scientific and technical management of an H&I laboratory service and its clinical interface in support of HSCT, be able to:

• analyse, synthesise, evaluate and apply knowledge
• perform a range of technical and clinical skills and procedures
• demonstrate the attitudes and behaviours necessary for professional practice as a consultant clinical scientist dealing with the complexities, uncertainties and tensions of professional practice at this level.

Knowledge and understanding

By the end of the training period the trainee will be able to demonstrate the ability to analyse, evaluate and synthesise relevant knowledge and its application to their professional practice in relation to the:

• different sources of stem cells used in current HSCT practice and the emerging developments in HSCT
• HLA and non-HLA factors relevant to the different types of HSCT
• clinical indications, complications and factors affecting outcome for HSCT
• appropriate H&I compatibility tests required for patient and donor pre-transplant workup and post- transplant monitoring
• advantages and disadvantages of the various sources of stem cells and different types of stem cell donors
• organisation and function of the various unrelated donor/cord registries
• criteria for selection and matching of recipients and stem cell donors
• legislation, standards and ethical issues relating to HSCT.

Technical and clinical skills

By the end of the training period the trainee will be able to demonstrate a critical understanding of current relevant research, theory and knowledge and its application to the performance of the following technical procedures and laboratory skills:

• select and perform the appropriate range of compatibility tests necessary for the pre-transplant workup of recipients and donors
• select and perform the appropriate range of post transplant monitoring tests for recipients and donors
• perform all stages of the unrelated donor/cord blood search process including identification and selection of the most appropriate donor/cord according to the clinical needs of the transplant recipient report results and provide relevant clinical commentary where necessary.
• report results and provide relevant clinical commentary where necessary.

By the end of the training period the trainee will be able to apply knowledge of an H&I laboratory service and its clinical interface in support of HSCT to perform the clinical skills necessary to manage under supervision to:

• participate at relevant MDT meetings, acting as a liaison between the laboratory and the HSCT team
• advise the clinical team with regard to compatibility of patient and donors
• prioritise workload according to the clinical need of the patients.