Blood and bone marrow transplantation

Details

Title

Blood and bone marrow transplantation

Type

Stage Two

Module code

HLS167

Requirement

Compulsory

Module objective

By the end of the training period trainees will, in respect of blood and bone marrow transplantation, be able to:

• analyse, synthesise, evaluate and apply knowledge
• perform, adapt and master a range of technical and clinical skills and procedures
• demonstrate the attitudes and behaviours necessary for professional practice as a consultant clinical scientist dealing with the complexities, uncertainties and tensions of professional practice at this level.

Knowledge and understanding

By the end of the training period the trainee will be able to demonstrate the ability to analyse, evaluate and synthesise relevant knowledge and its application to their professional practice in relation to

• concepts of autologous and allogeneic stem cell transplantation.
• bone marrow and mobilised peripheral blood, donor lymphocyte infusion, use of haematopoietic growth factors, selection of patients and donors for stem cell transplantation
• immunological basis for stem cell transplantation, role of histocompatibility and immunogenetics, consequences of antigen recognition, tolerance and rejection.
• graft-versus-leukaemia effect
• cell purification, enrichment and depletion using monoclonal antibodies, principles of cryopreservation techniques and theory of stem cell reinfusion protocols
• stem cell engraftment, including required cell dose, and immune reconstitution
• clinical aspects: indications for intensive chemotherapy and haematopoietic stem cell transplantation in the management of haematological malignancy, complications including graft-versus-host disease and procedure-associated morbidity/mortality. need for immunosupression in allogeneic recipients
• ethical aspects: informed consent, Human Tissue Act, regulatory bodies

Technical and clinical skills

By the end of the training period the trainee will be able to demonstrate a critical understanding of current relevant research, theory and knowledge and its application to the performance, adaptation and mastery of the following technical procedures and laboratory skills:

• have knowledge and understanding of the principles of cell manipulation and processing for stem cell transplants
• apply laboratory methods for processing and storing cells for transplantation
• have knowledge and critical understanding of the use of stem cell transplantation in haematological disease
• have knowledge and understanding of consent process and sample collection/storage of blood and marrow products.