Histocompatibility and Immunogenetics (H and I) in Blood Transfusion

Details

Title

Histocompatibility and Immunogenetics (H and I) in Blood Transfusion

Type

Stage Two

Module code

HLS190

Requirement

Compulsory

Module objective

By the end of the training period with respect to histocompatibility and immunogenetics in blood transfusion, the trainee will be able to:

• critically analyse, synthesise, evaluate and apply knowledge
• perform, adapt and master a range of technical and clinical skills and procedures
• demonstrate the attitudes and behaviours necessary for professional practice as a consultant clinical scientist dealing with the complexities, uncertainties and tensions of professional practice at this level

Knowledge and understanding

By the end of the training period the trainee will be able to demonstrate the ability to analyse, critically evaluate and synthesise relevant knowledge and its application to their professional practice in relation to:

• the principles of HLA and HPA typing, antibody detection and cross-matching techniques
• recognise the role of HLA, HPA and HNA typing in the selection and provision of blood components the principles of tests used for post-transplant monitoring
• the criteria for test selection and application to clinical speciality
• the limitations and clinical relevance of available tests
• the relevance and application of in-silico matching algorithms
• the relevance of blood transfusion to the development of HLA, HPA and HNA antibodies
• the role of H&I laboratory in the investigation of complications of blood transfusion and the provision of compatible blood components
• appropriate H&I tests required for the investigation of complications of blood transfusion and the provision of compatible blood components
• the process for selection of blood products for transfusion in the presence of HLA, HPA and HNA antibodies

Technical and clinical skills

By the end of the training period the trainee will be able to demonstrate a critical understanding of current relevant research, theory and knowledge and its application to the performance, adaptation and mastery of H&I in blood transfusion. Specifically the trainee will:

• express laboratory findings using appropriate HLA, HPA and HNA nomenclature.
• select and request appropriate H and I tests for the pre-transfusion and post-transfusion workup of patients sensitised to blood products
• select and request appropriate H and I tests for the investigation of transfusion reactions, e.g. transfusion-associated acute lung injury
• report results and provide relevant clinical commentary and advice where necessary

By the end of the training period the trainee will be able to apply knowledge of H and I in blood transfusion to perform, adapt and master the clinical skills necessary to:

• advise on the diagnostic value of H and I test results relating to blood transfusion therapy
• participate at relevant multi-disciplinary team meetings, acting as a liaison between the transfusion laboratory, the H and I laboratory, and the transfusion team
• advise the clinical team with regard to the selection and compatibility of patient and blood products
• advise the clinical team with regard to the outcome of investigations for transfusion reactions