Thrombocytopenia and Neutropenia in the Foetus, Neonate and Adult

Details

Title

Thrombocytopenia and Neutropenia in the Foetus, Neonate and Adult

Type

Stage Two

Module code

HLS191

Requirement

Compulsory

Module objective

By the end of the training with respect to thrombocytopenia and neutropenia in the foetus, neonate and adult, the trainee will be able to:

• analyse, synthesise, critically evaluate and apply knowledge
• perform, adapt and master a range of technical and clinical skills and procedures
• demonstrate the attitudes and behaviours necessary for professional practice as a consultant clinical scientist dealing with the complexities, uncertainties and tensions of professional practice at this level

Knowledge and understanding

By the end of the training period the trainee will be able to demonstrate the ability to analyse, critically evaluate and synthesise relevant knowledge and its application to their professional practice in relation to:

• the presentation and pathogenesis thrombocytopenias caused by platelet-specific antibodies including:
  • neonatal alloimmune thrombocytopenia
  • post-transfusion purpura
  • thrombocytopenia after stem cell transplantation
  • autoimmune thrombocytopenia
  • drug induced thrombocytopenia including heparin-induced thrombocytopenia
• the presentation and pathogenesis neutropenias caused by granulocyte-specific antibodies including:
  • neonatal alloimmune neutropenia
  • neutropenia after stem cell transplantation
  • transfusion-related alloimmune neutropenia
  • adult autoimmune neutropenia
  • autoimmune neutropenia of infancy
  • drug induce neutropenia
• isoimmune conditions including:
  • thrombasthenia
  • FcgRIII deficiency.
• laboratory detection and identification of platelet and granulocyte-specific antibodies including:
  • flow cytometric assays
  • monoclonal antibody immobilisation of platelet or granulocyte antigens
  • use of immobilised recombinant antigens
• fetal genotyping from fetal and maternal blood samples

Technical and clinical skills

By the end of the training period the trainee will be able to demonstrate a critical understanding of current relevant research, theory and knowledge and its application to the performance of the following technical procedures and laboratory skills:

• the detection and relevance of platelet-specific or granulocyte-specific antibodies to the differential diagnosis of autoimmune and alloimmune thrombocytopenia and neutropenias affecting the foetus, neonate and adult

By the end of the training period the trainee will be able to apply knowledge of the pathogenesis and laboratory diagnosis of thrombocytopenia and neutropenia to perform, adapt and master a range of clinical skills and will

• recommend to clinical colleagues an investigative approach to patients presenting with thrombocytopenia or neutropenia
• propose strategies to clinical colleagues to optimise the recognition and management of rare but clinically important disorders affecting subsequent pregnancies. including neonatal alloimmune thrombocytopenia
• advise clinical colleagues on the selection of compatible blood components for intra-uterine, neonatal and adult transfusion
• lead and evaluate education and training for nursing and medical staff involved in obstetric care to optimise the recognition and referral of high risk pregnancies