Myeloma Paraproteinaemias and Related Disorders

Details

Title

Myeloma Paraproteinaemias and Related Disorders

Type

Stage Two

Module code

HLS326

Requirement

Compulsory

Module objective

By the end of the training period trainees will, in respect to the myeloma, paraproteinaemias and related disorders, be able to

• analyse, synthesise, evaluate and apply knowledge
• perform, adapt and master a range of technical and clinical skills and procedures and
• demonstrate the attitudes and behaviours necessary for professional practise as a Consultant Clinical Scientist dealing with the complexities, uncertainties and tensions of professional practise at this level.

Knowledge and understanding

By the end of the training period the trainee will be able to demonstrate the ability to analyse, evaluate and synthesise relevant knowledge and its application to their professional practice in relation to:

• WHO classification of the paraproteinaemias including: Multiple Myeloma (MM), monoclonal gammopathy of undetermined significance (MGUS), solitary plasmacytoma, plasma cell lleukamia (PCL), Lymphoplasmacytic Lymphoma including Waldestrom’s Macroglobulinaemia (WM) and AL amyloidosis
• Laboratory and clinical phenotypic diagnosis, classification and staging
• Bone marrow morphology and cell surface marker analysis
• Cytogenetics and molecular genetics for clonal analysis and prognosis
• Bone disease and hypercalcaemia, hyperviscosity and amyloidosis
• Clinical aspects: clinical history, diagnosis including imaging techniques, treatment strategies including use of radiotherapy
• Role of chromosomal translocations and chromosomal gains/losses in the pathogenesis and clinical features of myeloma and other paraproteinaemias including IgH translocations, trisomies 3,5,7,9,11, 15, 19, 21, del13, hyperdiploidy
• Role of specific gene mutations including those affecting TP53, RAS, RB1, genetic components of the NF-kB pathway and others in the pathogenesis and clinical features of myeloma and related disorders.

Technical and clinical skills

By the end of the training period the trainee will be able to demonstrate a critical understanding of current relevant research, theory and knowledge and its application to the performance, adaptation and mastery of the following skills:

• Knowledge of practical laboratory aspects relating to diagnosis of myeloma and related disorders including biochemical immunoglobulin and other investigations, conventional bone marrow histology and cytology, immunohistochemistry, flow cytometry, conventional and interphase genetic investigations and molecular studies
• Advice to clinical and laboratory colleagues on the investigation of plasma cell disorders
• Multidisciplinary laboratory approach to diagnosis of myeloma and related conditions incorporating biochemical parameters, histology, immunohistochemistry, flow cytometry, genetic and molecular
• Ability to produce a fully interpretative clinical diagnostic laboratory report
• Understanding of clinical management of plasma cell disorders