HLA associations and Immunological Diseases

Details

Title

HLA associations and Immunological Diseases

Type

Stage Two

Module code

HLS336

Requirement

Compulsory

Module objective

By the end of the training period trainees will, in respect to a thorough understanding, theoretical and practical, of the knowledge, theoretical skills and clinical skills necessary to be proficient in the selection and interpretation of tests routinely used in the application of HLA associations and immunological diseases, be able to:

• analyse, synthesise, evaluate and apply knowledge
• perform, adapt and master a range of technical and clinical skills and procedures and
• demonstrate the attitudes and behaviours necessary for professional practise as a Consultant Clinical Scientist dealing with the complexities, uncertainties and tensions of professional practise at this level.

Knowledge and understanding

By the end of the training period the trainee will be able to demonstrate the ability to analyse, evaluate and synthesise relevant knowledge and its application to their professional practice in relation to the:

• immunological investigations of different HLA diseases association
• investigation by other specialities involved (rheumatology, gastroenterology etc) in the management of these patients
• HLA haplotypes and inheritance.
• Genetic markers determining the risk for the development of certain diseases including, e.g. HLA-B27 with ankylosing spondylitis, birdshot chorioretinopathy HLA-A29, Behçet’s disease HLA- B51, rheumatoid arthritis Amino acids 70-74 on the DRB1 gene (QKRAA or QRRAA), Narcolepsy HLA- DQB1*06:02/DQA1*01:02, Coeliac disease HLA-DQB1*02/DQA1*05, DQB1*03:02, Selective IgA deficiency HLA-DRB1*03:01/DQB1*02
• Proposed mechanisms of HLA polymorphisms and disease susceptibility/protection.
• HLA genes associated with drug sensitivity i.e. Abacavir sensitivity HLA-B*57:01
• human immunodeficiency virus (HIV) and AIDS , pathogenesis of HIV infection , Epidemiology, prevalence and modes of transmission, management of HIV infection (drug therapies: vaccines)
• Role of HLA in cancer immunotherapy.

Technical and clinical skills

By the end of the training period the trainee will be able to demonstrate a critical understanding of current relevant research, theory and knowledge and its application to the performance, adaptation and mastery of the following skills:

• Understand the laboratory investigations and other specialist investigations for pharmacogenetic, immunotherapeutic and disease associations with HLA
• Laboratory abnormalities in HIV infection (CD4 counts, viral loads).
• Analyse and interpret test results and identify requirements for further testing.

By the end of the training period the trainee will be able to apply knowledge of the general principles of the techniques used in the application of HLA associations and immunological diseases to perform, adapt and master the clinical skills necessary to manage and to understand the:

• clinical presentations of these diseases
• interpretation of results with immunological and specialist results to determine risk factors and management of patients.