Genetics of haematological malignancies leukaemia and lymphoma

Details

Title

Genetics of haematological malignancies leukaemia and lymphoma

Type

Stage Two

Module code

HLS429

Requirement

Compulsory

Module objective

By the end of the training period trainees will, in respect of genetics of haematological malignancies (leukaemia and lymphoma), understand the rationale of genetics screening and testing for cancer medicine and be able to:

• analyse, synthesise, evaluate and apply knowledge
• perform adapt and master a range of scientific and clinical skills and procedures understand the technical principles and processes underpinning these skills
• demonstrate the attitudes and behaviours necessary for professional practice as a consultant clinical scientist dealing with the complexities, uncertainties and tensions of professional practice at this level.

(* acquired haematological disorders to include: acute leukaemia, chronic leukaemia, multiple myeloma and other plasma cell dyscrasis, Hodgkins and non-Hodgkin’s lymphoma, myelodysplastic disorders, MPN.)

Knowledge and understanding

By the end of the training period the trainee will be able to demonstrate the ability to analyse, evaluate and synthesise relevant knowledge and its application to their professional practice in relation to the:

• pathogenesis and diagnosis of acquired haematological disorders.
• classification, staging systems and prognostic factors and any implications for therapy use of trial protocols.
• principles and limitations of autologous and allogenic haematopoietic stem cell transplantation in management of disease.
• underlying principles of available cytogenetic and molecular genetics tests.

Technical and clinical skills

By the end of the training period the trainee will be able to demonstrate a critical understanding of current relevant research, theory and knowledge and its application to the performance, adaptation and mastery of the following technical procedures and laboratory skills:

• selection and use of appropriate sample and preparation types including minimal
• sample requirements and storage/transit life
• sample preparation
• cytogenetic chromosome analysis
• FISH using single/panel probe sets
• molecular -PCR, RT-PCR, sequencing.

By the end of the training period the trainee will be able to apply knowledge of genetics of haematological malignancies (leukaemia and lymphoma), to perform, adapt and master the clinical skills necessary to manage the:

• appropriate cytogenetic and/or molecular genetic laboratory investigations to establish diagnosis
• appropriate investigations in monitoring/staging of disease.
• test results and writing of interpretative clinical reports
• management plan in the setting of MDT
• test results with other healthcare professionals and patient/family.
• timeliness of tests in the context of presentation and test results.