Training activity information
Details
Interpret and draft a clinical report for NGS for the diagnosis and treatment decisions of lymphoid disorders
Type
Entrustable training activity (ETA)
Evidence requirements
Evidence the activity has been undertaken by the trainee repeatedly, consistently, and effectively over time, in a range of situations. This may include occasions where the trainee has not successfully achieved the outcome of the activity themselves. For example, because it was not appropriate to undertake the task in the circumstances or the trainees recognised their own limitations and sought help or advice to ensure the activity reached an appropriate conclusion.
Reflection at multiple timepoints on the trainee learning journey for this activity.
Considerations
- Principles of the molecular testing strategy including targeted vs whole genome vs exome
- NGS QC matrix, IQC and EQA and its role in troubleshooting
- Bioinformatics tools for the identification of variants
- Classification of variant pathogenicity/actionability according to BPG, internal policy and the appropriate online databases
- Considerations concerning inherited variants
- Best practice guidelines for reporting, including recommendations for patient treatment and management, follow up, further testing or clinical trials if relevant
- Correct scientific and clinical terminology, including HGVS nomenclature
- Communication of complex scientific information to the multidisciplinary team
Relevant learning outcomes
| # | Outcome |
|---|---|
| # 4 |
Outcome
Analyse, interpret and prepare interpretive reports for common haematological malignancies, including results for somatic variants, clonality, and somatic hypermutation. |
| # 5 |
Outcome
Interpret the associated IQC and EQA of the laboratory tests for investigation of haematological malignancies. |
| # 6 |
Outcome
Practice with the relevant specialties for the diagnosis, monitoring and management of haematological malignancies. |