Competency information
Details
Identify the group/phenotype of red cells required for safe transfusion where blood grouping is not straightforward.
Considerations
- Correct selection of red cell and plasma-rich blood components throughout the chimerism of a HSCT:
- major mismatch
- minor mismatch
- bi-directional mismatch.
- Risks of abbreviated testing for ABO.
- Additional requirements for blood components for immunocompromised patients.
- Rare blood group problems, including Bombay phenotype.
- Dealing with patients with multiple populations of cells – recently transfused patients, post HSCT.
- Unexpected results in reverse grouping :
- presence of atypical red cell antibodies
- AIHAs
- neonates
- immunosuppressed patients
- large volume transfusion
- hyper- /hypo-gammaglobulinaemias.
- Reasons for weak antigen expression in patients.
- Unexpected reactions in forward grouping, e.g. acquired B.
Relevant learning outcomes
| # | Outcome |
|---|---|
| # 1 | Outcome Troubleshoot serological tests, investigate patient and donor blood grouping anomalies, and make interpretations in clinical context. |