Competency information
Details
Perform a range of methods for diagnosing and monitoring treatment of haematological malignancy, including:
- fluorescence in-situ hybridisation
- molecular diagnostics, including:
- IGH gene rearrangement and/or TCR gene rearrangement
- BCRABL
Considerations
- The principles underlying the methods listed
- Understanding of BCSH guidelines for selection of appropriate tests
- Relevant white cell morphology (bone marrow and peripheral blood)
- Molecular tests from the following list:
- IgH gene rearrangement and/orTCR gene rearrangement
- BCRABL
- JAK2 and/or CALR
- FLT3/NPMI
- The need for internal and external quality assessment and how to remedy poor performance
Relevant learning outcomes
| # | Outcome |
|---|---|
| # 1 | Outcome Receive, prepare and process specimens for solid tumour investigation To include supervised dissection, tissue selection cutting, fixation and staining, as appropriate |
| # 2 | Outcome Receive, prepare and process specimens for haematological malignancy investigation To include sampling methods, correct sample procedures, collection and storage of samples nucleic acid extraction and quality assessment |
| # 4 | Outcome Recognise normal cellular morphology of representative tissues and organs and common pathobiological processes associated with them |
| # 5 | Outcome Perform a range of laboratory techniques used in screening and investigating histopathological and haematological malignancy disorders |
| # 6 | Outcome Apply the principles of internal quality control and external quality assessment and draw conclusions about assay performance |
| # 7 | Outcome Use laboratory IT systems for the safe handling, processing and storage of patient data |