Competency information
Details
Analyse and interpret genetic analysis for Ph-negative myeloproliferative malignancies
Considerations
- Health and safety requirements for processing of fresh peripheral blood or bone marrow samples
- Principles of molecular genetic approaches relevant for diagnostic approaches for the Ph- negative myeloproliferative malignancies
- Analysis and interpretation of single nucleotide variation in tyrosine kinase inhibitor genes eg JAK2 pV617F
- Analysis and interpretation of other pathogenic variants relevant for the diagnosis and management of Ph-negative myeloproliferative malignancies (eg CALR mutations)
- Factors affecting quality of samples for molecular genetic analysis
- Limitations of the procedures
- Internal quality control for assays
- Importance of external quality assurance
- Role of validation and verification of procedures and equipment
- Understanding of assay accreditation and ISO 15189 or equivalent
- National guidelines for pathways and procedures
Relevant learning outcomes
| # | Outcome |
|---|---|
| # 3 | Outcome Apply the appropriate testing strategy that would lead to the diagnosis of a range haematological malignancies |
| # 4 | Outcome Implement the use of appropriate assays for the diagnoses and monitoring of a range of haematological malignancies |