Module information

Module details

Advanced Therapies and Stem Cells
Module code

Aim of this module

This module will enable trainees to develop their knowledge of stem cell transplantation and advanced therapies and improve understanding of the application in the treatment of a range of haematological disorders.

Work-based content

Training activities

# Learning outcome Training activity Type Action
# 1 Learning outcome 1 Training activities

Perform an audit of sample storage to ensure compliance with the Human Tissue Authority (HTA)

Type DTA Action View
# 2 Learning outcome 2,3 Training activities

Select the appropriate monitoring methods for patients treated with novel and emerging therapies which may interfere with standard assays

Type DTA Action View
# 3 Learning outcome 1,3,4 Training activities

Appraise a clinical trial protocol

Type DTA Action View
# 4 Learning outcome 1,2,3 Training activities

Measure CD34 positive stem cells in a donated sample by flow cytometry

Type DTA Action View
# 5 Learning outcome 1,3 Training activities

Interpret results of cfDNA assay and suggest further actions for treatment/therapy

Type DTA Action View
# 6 Learning outcome 1,3 Training activities

Prepare a case study where ALLO transplantation has been used for treatment

Type DTA Action View
# 7 Learning outcome 1,3 Training activities

Review post ALLO transplant monitoring data and advise on next steps and follow up

Type DTA Action View
# 8 Learning outcome 1,3 Training activities

Present a case report of a patient undergoing novel therapy as part of a clinical trial

Type DTA Action View
# 9 Learning outcome 1,3 Training activities

Assist with the clinical laboratory work-up of patients awaiting haemopoietic stem cell transplantation

Type DTA Action View
# 10 Learning outcome 1,3 Training activities

Present a case study of a patient undergoing treatment or treated with a personalised medicine strategy

Type DTA Action View


Complete 2 Case-Based Discussions

Complete 2 DOPS or OCEs

Direct Observation of Practical Skills Titles

  • Perform tests to monitor post-transplant engraftment.
  • Draft a report for the results of a cfDNA assay.
  • Select suitable blood products for a patient who has had a stem cell transplant.
  • Assess patient eligibility for a clinical trial.

Observed Clinical Event Titles

  • Discuss testing appropriateness with a healthcare professional.
  • Obtain informed consent from a patient for a procedure, including an explanation of the risk and benefits of the procedure to the patient.

Learning outcomes

# Learning outcome

Practice in accordance with legislation regarding use of human tissue.


Apply laboratory techniques to support the use of stem cells in the treatment of haematological conditions.


Appraise the application of novel and evolving therapies in the treatment of haematological conditions.


Evaluate the application of gene therapy for the treatment for malignant and non-malignant haematology.

Clinical experiences

Clinical experiences help you to develop insight into your practice and a greater understanding of your specialty's impact on patient care. Clinical experiences should be included in your training plan and you may be asked to help organise your experiences. Reflections and observations from your experiences may help you to advance your practice and can be used to develop evidence to demonstrate your awareness and appreciation of your specialty.


  1. Observe a stem cell harvest.
  2. Attend ward rounds and clinics at which patients are being worked up for or monitored following haematopoieticstem cell transplantation.
  3. Attend a multidisciplinary review meeting at which laboratory results are presented for patients awaiting transplant or being monitored following haematopoieticstem cell transplantation.
  4. Attend or access a patient forum or local support group to appreciate patient experiences and context.
  5. Shadow a nurse specialist providing pastoral care to patients.

Academic content (MSc in Clinical Science)

Important information

The academic parts of this module will be detailed and communicated to you by your university. Please contact them if you have questions regarding this module and its assessments. The module titles in your MSc may not be exactly identical to the work-based modules shown in the e-portfolio. Your modules will be aligned, however, to ensure that your academic and work-based learning are complimentary.

Learning outcomes

On successful completion of this module the trainee will be able to:

  1. Critically appraise the use of monoclonal antibodies in haematological disorders.
  2. Critically evaluate the role of stem cell, cord blood and CAR-T cells.
  3. Critique how gene therapy plays a role in the management of patients with malignant and non-malignant haematology.

Indicative content

  • Regulations.
  • Clinical trials protocols and consent processes.
  • Clinical indications.
  • Sources and generation of stem cells- registries, cord blood.
  • CAR-T cells.
  • Personalised treatment protocols.
  • Precision medicine.

Module assigned to


Specialty code Specialty title Action
Specialty code SLS1-2-22 Specialty title Haematology & Transfusion Science [2022] Action View
Specialty code SLS1-2-23 Specialty title Haematology & Transfusion Science [2023] Action View
Specialty code SLS1-2-24 Specialty title Haematology & Transfusion Science [2024] Action View