Title Background and principles
Type Stage One
Code HLS000
Requirement Compulsory

Module objective

By the end of the training period trainees will, in respect to background and principles, be able to:

  • Analyse, synthesise, evaluate and apply knowledge
  • Perform a range of technical and clinical skills and procedures
  • Demonstrate the attitudes and behaviours necessary for professional practice as a consultant clinical scientist dealing with the complexities, uncertainties and tensions of professional practice at this level.

Knowledge and understanding

By the end of the training period the trainee will be able to demonstrate the ability to analyse, evaluate and synthesise relevant knowledge and its application to their professional practice in relation to:

  • basic physiology (liver, lung, kidney, brain, blood, circulation, etc.) and their integration and control
  • xenobiotic disposition; absorption, distribution, elimination; biotransformation and transport systems
  • exposure assessment and identification of suitable endpoints in the interpretation of toxicology data, including the importance of routes of exposure
  • dose response relationships, threshold and non-linear models, derivation of no observed (adverse) effect levels [NO(A)ELs], lowest observed (adverse) effect levels [LO(A)EL], therapeutic indices (TI), acceptable daily intake (ADI) and tolerable daily intake (TDI), maximum residue levels (MRLS)
  • pharmacodynamics and pharmacokinetics
  • sample collection, transport, and storage, and analysis of biological fluids/tissues in chemical pathology, haematology, and histopathology
  • principles of ecotoxicology
  • principles of risk/safety assessment pertaining to humans, animals and the environment
  • principles of therapeutics, adverse drug reactions, pharmacovigilance
  • principles and use of alternative methods to the use of animals for safety assessment.

Technical and clinical skills

This module has no technical and clinical skills.

Attitudes and behaviours

This module has no attitude and behaviours information.


Code Title Action
HLS1-5-20 Analytical Toxicology [v1] View