Title Laboratory aspects of Histocompatibility and Immunogenetics
Type Stage One
Code HLS042
Requirement Compulsory

Module objective

By the end of the training period trainees will, in respect to the techniques used in the application of H&I services, obtain a working knowledge of the scientific, clinical and technical aspects of H&I and be able to:

  • analyse, synthesise, evaluate and apply knowledge
  • perform a range of technical skills and procedures
  • demonstrate the attitudes and behaviours necessary for professional practice as a consultant clinical scientist dealing with the complexities, uncertainties and tensions of professional practice at this level

Knowledge and understanding

By the end of the training period the trainee will be able to demonstrate the ability to analyse, evaluate and synthesise relevant knowledge and its application to their professional practice in relation to:

  • the principles of HLA typing, antibody detection and cross-matching techniques
  • the principles of tests used for post-transplant monitoring
  • the criteria for test selection and application to clinical speciality
  • the limitations and clinical relevance of available tests
  • the principles of validation procedures for equipment and tests
  • internal and external quality assurance processes
  • the relevance of in-silico assays, e.g. HLA matchmaker.

Technical and clinical skills

By the end of the training period the trainee will be able to demonstrate a critical understanding of current relevant research, theory and knowledge and its application to the performance of the following technical procedures and laboratory skills:

  • perform unsupervised the technical procedures used for:
    • HLA typing
    • antibody detection and specification
    • cross-matching
    • post-transplant monitoring
  • analyse and interpret test results
  • perform procedures to validate results, e.g. family pedigree information
  • produce timely, accurate and relevant laboratory reports with appropriate interpretive comments
  • reports test results using correct HLA nomenclature
  • uses appropriate level of nomenclature according to reporting requirements
  • be familiar with systems used for assuring the quality of tests procedures and reagents
    • use appropriate internal controls and monitoring assay performance
    • achieve satisfactory performance in internal and external quality control exercises
  • assess and resolve technical issues and test anomalies
  • identify and analyse the potential utility of new technologies.


By the end of the training period the trainee will be able to apply knowledge of techniques used in the application of H&I services to perform the clinical skills necessary to manage under supervision and gain:

  • the competence to provides clinical advice on requirements for additional/subsequent tests
  • the competence to advise on the diagnostic value of test results.

Attitudes and behaviours

This module has no attitude and behaviours information.


Code Title Action
HLS1-4-20 Histocompatibility & Immunogenetics [v1] View