Title Bleeding disorders Von Willebrand disease
Type Stage Two
Code HLS156
Requirement Compulsory

Module objective

By the end of the training period trainees will, in respect of bleeding disorders – Von Willebrand disease, be able to:

  • analyse, synthesise, evaluate and apply knowledge
  • perform, adapt and master a range of technical and clinical skills and procedures
  • demonstrate the attitudes and behaviours necessary for professional practice as a consultant clinical scientist dealing with the complexities, uncertainties and tensions of professional practice at this level.

Knowledge and understanding

By the end of the training period the trainee will be able to demonstrate the ability to analyse, evaluate and synthesise relevant knowledge and its application to their professional practice in relation to

  • pathogenesis, severity and symptoms
  • VWF synthesis, structure and function
  • genetics and inheritance
  • laboratory and clinical phenotypic diagnosis and classification
  • laboratory investigation (VWF:Ag, VWF functional assays, VWF multimer assay, VWF–FVIII binding studies etc)
  • the role of genetic diagnosis in VWD
  • clinical aspects and presentation
  • acquired VWD
  • clinical aspects: clinical history, bleeding score, treatment principles and measures
  • clotting factor replacement therapy and prophylaxis, DDAVP, cryoprecipitate, tranexamic acid
  • treatment complications: inhibitors, thrombosis.

Technical and clinical skills

By the end of the training period the trainee will be able to demonstrate a critical understanding of current relevant research, theory and knowledge and its application to the performance, adaptation and mastery of the following technical procedures and laboratory skills:

  • have knowledge of pathogenesis, genetics and clinical and laboratory aspects of inherited and acquired VWD
  • give advice to clinical and laboratory colleagues on the investigation of VWD
  • understand the clinical management of inherited bleeding disorders.

Attitudes and behaviours

This module has no attitude and behaviours information.


Code Title Action
HLS1-2-1-20 Haematology (Haemostasis and Thrombosis) [v1] View