Title Haematopoietic stem cell transplantation 2
Type Stage Two
Code HLS179
Requirement Compulsory

Module objective

By the end of the training period trainees will, in respect of developing skills and knowledge required for provision of clinical advice on all aspects of H&I in haematopoietic stem cell transplantation be able to:

  • analyse, synthesise, evaluate and apply knowledge
  • perform, adapt and master a range of technical and clinical skills and procedures
  • demonstrate the attitudes and behaviours necessary for professional practice as a consultant clinical scientist dealing with the complexities, uncertainties and tensions of professional practice at this level.

Knowledge and understanding

By the end of the training period the trainee will be able to demonstrate the ability to analyse, evaluate and synthesise relevant knowledge and its application to their professional practice in relation to the:

  • factors influencing transplant outcome
    • HLA matching
    • ABO matching
    • CMV status
    • other gene polymorphisms
    • HLA antibodies
    • donor/recipient characteristics
    • immunosuppressant regimes
  • impact of factors above in assessment of risk
  • impact of factors above in assessing likelihood of finding a donor
  • operation of national and international unrelated cord and haemopoietic stem cell registries
  • use and application of in-silico assays, e.g. Histocheck
  • action and interaction of Immunosuppressive therapies used in HSCT.

Technical and clinical skills

By the end of the training period the trainee will be able to demonstrate a critical understanding of current relevant research, theory and knowledge and its application to the performance, adaptation and mastery of the following technical procedures and laboratory skills:

  • plan appropriate testing strategy for patients according to source of transplant
  • analyse and interpret test results and identify requirements for further testing.

By the end of the training period the trainee will be able to apply knowledge of haematopoietic stem cell transplantation to perform, adapt and master the clinical skills necessary to manage to:

  • interpret and apply findings of individual and multiple tests to provide clinical advice relevant to:
    • selection of appropriate donors or recipients for transplantation and assessment of risk
    • likelihood of finding a suitable donor
    • engraftment and relapse
    • requirements for and success of post-transplant treatment for relapse and delayed engraftment
  • apply knowledge of professional guidelines and standards to strategies for patient management
  • participate in multi-disciplinary meetings and is able to assimilate clinical and laboratory findings with other relevant factors to contribute to individual patient treatment plans.

Attitudes and behaviours

This module has no attitude and behaviours information.


Code Title Action
HLS1-4-20 Histocompatibility & Immunogenetics [v1] View