Genetic Basis of Haematopoietic Neoplasms

Details

Title

Genetic Basis of Haematopoietic Neoplasms

Type

Stage Two

Module code

HLS322

Requirement

Compulsory

Module objective

By the end of the training period trainees will, in respect to developing skills and knowledge required for understanding the genetic basis of haematopoietic neoplasms be able to

• analyse, synthesise, evaluate and apply knowledge
• perform, adapt and master a range of technical and clinical skills and procedures and
• demonstrate the attitudes and behaviours necessary for professional practise as a Consultant Clinical Scientist dealing with the complexities, uncertainties and tensions of professional practise at this level.

Knowledge and understanding

By the end of the training period the trainee will be able to demonstrate the ability to analyse, evaluate and synthesise relevant knowledge and its application to their professional practice in relation to:

• understanding DNA structure and gene expression, organisation of the human genome, inheritance, somatic and germline mutations and mutational mechanisms
• having core knowledge and understanding of human molecular genetics and the molecular basis of many diseases, including premalignant disease and cancer
• understanding the genetic abnormalities associated with clonal proliferation in malignant haematological disease and the role, application and clinical interpretation of molecular genetics for diagnosis, prognosis and monitoring following therapy
• methodology, principles and practice, assay design, trouble-shooting: PCR, linkage analysis, mutation screening, DNA sequencing
• interpretation of array CGH data
• interpretation of gene expression profiling data
• knowledge and understanding of ethical aspects of diagnosis and sample collection/storage in haematological disorders
• impact of pharmacogenomics on the management of patients with haematological malignancies.

Technical and clinical skills

By the end of the training period the trainee will be able to demonstrate a critical understanding of current relevant research, theory and knowledge and its application to the performance, adaptation and mastery of the following technical procedures and laboratory skills:

• technical and practical aspects of molecular biology methods for the investigation of haematological malignancy
• appropriate use of molecular biology investigations to establish diagnosis and to produce a fully interpretative clinical diagnostic laboratory report.