Haematopoietic Stem Cell Transplantation

Module details

Title

Haematopoietic Stem Cell Transplantation

Type

Specialist

Module code

SLS129

Credits

10

Requirement

Compulsory

Aim of this module

This module will provide the trainee with a knowledge and understanding of stem cell donation, testing, harvesting and monitoring. They will understand a range of clinical conditions associated with stem cell transplantation requirements. They will gain experience of HLA typing in the matching of donors and suitable recipients. In the work-based module they will be expected to apply this knowledge as they learn to perform relevant laboratory methods and gain experience of the interpretation of patient results in a variety of clinical settings.

This module will provide the trainee with the practical application of knowledge and skills relating to Histocompatibility and Immunogenetics techniques applicable to haematopoietic stem cell transplantation.

 

Competencies

#	Learning outcome	Competency	Action
# 1	Learning outcome 1	Competency Analyse family HLA results to produce pedigree data.	Action View
# 2	Learning outcome 1,2	Competency Review and select potential related  donors for HSCT, using local and national protocols.	Action View
# 3	Learning outcome 1,2	Competency Review and select potential unrelated adult donors for HSCT, using local and national protocols.	Action View
# 4	Learning outcome 1,2	Competency Review and select potential cord donors for HSCT, using local and national protocols.	Action View
# 5	Learning outcome 1,2,3,5	Competency Assess the suitability of potential related and unrelated (adult and cord blood) donors for HSCT, using local and national protocols	Action View
# 6	Learning outcome 1,2,3,5	Competency Produce an interpretive report of the suitability of potential related and unrelated (adult and cord blood) donors for HSCT for clinical colleagues.	Action View
# 7	Learning outcome 1,4	Competency Perform chimerism analysis to assess and monitor patients post HSCT.	Action View
# 8	Learning outcome 1,4,5	Competency Produce an interpretive chimerism report for clinical colleagues, using local and national protocols.	Action View
# 9	Learning outcome 5	Competency Work in partnership with other clinical specialisms in the investigation of haematopoietic stem cell transplantation and, where appropriate with service users and support staff.	Action View
# 10	Learning outcome 5	Competency Communicate effectively with the healthcare team recognising and responding appropriately to situations where it is necessary to share information to safeguard service users or the wider public.	Action View

Assessments

You must complete:

• 2 case-based discussion(s)
• 2 of the following DOPS/ OCEs:

Prepare an interpretive family pedigree report	DOPS
Conduct a search for an unrelated stem cell donor	DOPS
Conduct a search for an unrelated cord blood donor	DOPS
Prepare an interpretive report of the suitability of potential related and unrelated donors	DOPS
Perform tests to monitor post- transplant engraftment	DOPS
Prepare an interpretive report for chimerism monitoring	DOPS
Attend ward rounds and/or clinics at which patients are being worked up for, or monitored following haematopoietic stem cell transplantation and describe to the patient the involvement of the Laboratory in their care	OCE
Attend a multidisciplinary review meeting at which laboratory results are presented and describe to colleagues what they mean.	OCE
Take a patient history	OCE

Learning outcomes

1. Perform the clinical and laboratory investigation of patients being considered for HSCT including the interpretation and reporting of results in the correct clinical context.
2. Select suitable donors for HSCT under supervision.
3. Assess the suitability of potential related and unrelated (adult and cord blood) donors for HSCT.
4. Perform clinical and laboratory monitoring of patients who have received haematopoietic stem cell transplantation.
5. Work in partnership with other clinical specialisms in the investigation of haematopoietic stem cell transplantation and, where appropriate, with service users and support staff.

Learning outcomes

1. Explain the role of HSCT in the treatment of various haematopoietic disorders.
2. Know the nomenclature of the HLA system and discuss its role in the selection of donors for HSCT.
3. Describe the design, operation and performance of HLA typing methods for HSCT according to current guidelines.
4. Explain the principles of post-transplant monitoring and its role in patient management.
5. Describe the partnership between histocompatibility and immunogenetics and other clinical specialisms in the investigation of HSCT and patient care.

Indicative content

• Principles of HSCT
• HLA genetics and nomenclature
• Stem cell sources
• Principles of donor selection
• Pre-transplant work-up
• Compatibility testing
• Stem cell registries – Bone Marrow Donors Worldwide (BMDW), Anthony Nolan Trust (ANT), Worldwide Network for Blood and Marrow Transplantation (NetCord)
• Principles of post-transplant monitoring
• Graft versus host disease and graft versus leukaemia
• Legislation: Joint Accreditation Committee – ISCT & EBMT (JACIE), Human Tissue Authority (HTA), European Federation for Immunogenetics (EFI), Foundation for the Accreditation of Cellular Therapy (FACT)

 

Activities

• Actively participate in ward rounds and clinics at which patients are being worked up for or monitored following haematopoietic stem cell transplantation. Discussion and critical reflection of your experiences, including ethical issues, and the involvement of the laboratory in the management of patients.
• Actively participate in multidisciplinary review meetings at which laboratory results are presented as part of the clinical record in patients awaiting or being monitored following haematopoietic stem cell transplantation. Identify how your experience will impact on your future practice as a clinical scientist.
• With permission talk to a patient and family and explore their experience of transplantation and critically reflect on your learning and how it will affect your future practice
• Critically reflect on your own experience of supervision and mentoring and identify how you will use these in your learning training, supervising and mentoring of others.